He was also frequently embarrassed by having to be saved by the Rain Master multiple times due to their history of when they were mortals, even refusing her offer of borrowing her sword because of it. While he loves them and is shown to treat them with tender and protective care, never to foster false hopes or play with feelings, he also possesses quite traditional expectations of women like cooking skills, although they are arguably common views for the time. In addition, it's stated that Pei Ming is overall hard to describe when it came to women. However, he dislikes strong-willed and forceful women like Xuan Ji. He is a well known womanizer and flirt among the three realms. His voice sounds lyrical, adding to the alluring characteristics. He has an exceedingly handsome, graceful and charming appearance, being the type that "could definitely steal hearts". Ph.D.Pei Ming is a tall man of around twenty-six to twenty-seven years.
I am currently working on developing a new set of luciferase-based reporters to distinguish the effects of readthrough drugs and NMD inhibitors on PTCs and NTCs. For PTC suppression therapy to be viable in the clinic, it will be important to test whether readthrough compounds and/or NMD inhibitors identified by HTS do not affect NTCs. Prior research in this area has been largely inconclusive. Meanwhile, I am also interested in whether those potential readthrough drugs and NMD inhibitors discovered by HTS could also affect normal termination codons(NTCs). We will further conduct suppression effect of those newly discovered pharmaceutical compounds in cell based and animal models of two genetic diseases, cystic fibrosis (CF) and mucopolysaccharidosis I-Hurler (MPS I-H) that we developed in previous studies. We are currently working intensively on testing and verifying those potential PTC suppression drugs and NMD inhibitors. Several initial hits have been identified. Bedwell and Keeling labs, we have developed a variety of NanoLuc-luciferase-based mammalian readthrough/NMD reporter cell lines, and those cell lines have been utilized for a high throughputscreen (HTS) to discover new drugs that suppress PTCs and/or inhibit NMD. I am currently exploring the possibility of combining these two approaches as a viable therapeutic strategy to treat a range of genetic diseases caused by PTCs. Another approach is to inhibit nonsense-mediated mRNA decay (NMD) pathway to increase the abundance of the mRNA harboring PTCs, which serves as the template for protein translation. One treatment uses low molecular weight compounds to induce read through at PTCs in order to generate full-length proteins. Currently, two main therapeutic approaches have been intensively investigated to treated PTCs-caused genetic diseases.
I am interested in the treatment of genetic diseases caused by premature termination codons (PTCs).
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